Director Immunoinflammation GSK Stevenage

Job Description
In this newly created role in GSK R&D Bioelectronics unit, the Immuno-inflammation Disease Director and the team that (s)he builds will advance and a focused (pre)clinical research pipeline for chronic in immuno-inflammation disease with the objective to shape the rapid path to compelling clinical demonstration. (S)he will be responsible for driving the portfolio through collaboration with members of the Bioeletronics Leadership team, scaling up existing projects and driving new collaborations with Key Opinion Leaders/Principal investigators and ensuring effective alliances with external CROs and regulatory bodies.

The Successful Candidate Will Join The Bioelectronics Treatment Discovery Team And Will Be Accountable For

Delivering a portfolio of clinical projects for the treatment of immuno-inflammation disease

Lead and/or Manage projects acting as the Early Development Leader/Medicine Development Leader for advanced clinical projects

Lead work streams with the Experimental Medicine Director, the Treatment Discovery Head and external KOLs in order to ensure early clinical studies in patients have clear testable hypothesis and end points that allow a decision on further progression and investment

Lead projects ensuring funding is secured and partnerships are established with Clinical Research and Contract Research Organisations to facilitate delivery of clinical trials

Be responsible for ensuring the appropriate preclinical packages (safety/efficacy) are generated in order to support clinical progression

Be responsible for ensuring regulatory documents are complied and submitted (eg Investigator Brochures, clinical protocols) and approval is gained through engagement with the relevant internal medical governance boards and external regulatory bodies

Shape a focused portfolio of new preclinical projects for the treatment of immuno-inflammation disease

Lead the immuno-inflammation discovery portfolio ensuring projects are prioritized, funded and delivered to agreed timelines

Work with the Disease Biology function and the Bioelectronic Leadership team to ensure new opportunities for immuno-inflammation disease are identified, critiqued and prioritized, establishing a focused, sustained portfolio of discovery projects

Be responsible for ensuring all discovery projects are efficiently prosecuted through collaboration with external PIs establishing testable, budgeted project plans that allow for a clear assessment of therapeutic opportunity

Lead work streams with the Research Platform group to ensure all projects have strategies for chronic neuromodulation

Work closely with Experimental Medicine Director to ensure appropriate data is generated to facilitate early Experimental Med studies in patients

Build and line-manage a team that is accountable for delivering the immuno-inflammation portfolio through establishing a network of internal/external disease experts

LEADERSHIP

Provide preclinical and project leadership to early development teams in the design and delivery of translational medicine studies that deliver answers to key clinical questions

Seek external KOLs/PIs to solidify early clinical plans

Be an advocate both internally and externally for the high quality work that the Unit is engaged in

Lead by example in terms of day to day behaviours consistent with GSK Values and Behaviours

ENSURING DELIVERY OF KEY BUSINESS GOALS

Deliver studies that demonstrate proof of mechanism and concept in exploratory clinical development.

Drive the delivery of new experimental clinical development paradigms in areas of high priority to the unit’s portfolio.

Work with external clinical investigators, internal GSK functions (CPSSO, QSci, CUC, regulatory), academic and CRO groups to deliver clinical studies on time and on budget.

Work to enhance disease knowledge and understanding, target alignment and patient stratification using shared resources and collaborations

Ensure timely integration and dissemination of clinical data to the unit

Optimise use of resources internally and externally

RELATIONSHIPS AND STRATEGY

Build strong relationships across the bioelectronic unit and the external bioelectronics research community in order to ensure an integrated clinical strategy

Build strong partnerships with internal disease area experts, external KOLs and establish and Scientific Advisory Boards where appropriate

Build strong relations with clinical groups across GSK especially in those groups that have a strong local presence

Build strong links with Late phase development and Medicine Development Leaders in order to integrate late stage thinking into early clinical plans

Work within the matrix disseminate understanding of translational medicine

Interact with other senior matrix leadership teams on key advisory and safety review boards

Qualifications

PhD and/or MD level

This role requires a world renowned immunologist with demonstrated research experience

He/she will be a scientist with a strong passion for translational research and a deep understanding of immunology. He/she will have an understanding of translational science and experimental medicine.

Demonstrated ability to drive innovative science and scientific challenge and debate

Previous experience of neuro-modulation is preferred but not required

Clear ability to think strategically, ask the right biological questions,establish vision and goals, and shape value propositions in new treatment approaches for patients and physicians

Excellent leadership skills that will drive the science and delivery of the early projects

Excellent matrix management, networking and communication skills (written, verbal) – proven ability to influence across a large organisation

Proven ability to lead preclinical projects through to clinical studies

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